姓名：臧大维

邮箱：dawei656@163.com

工作单位、科室：天津市第一中心医院神经内科

职称：主任医师/教授

研究方向/擅长领域：脑血管病，神经变性病

教育、工作经历：

1989年-2000年：北京市天坛医院神经内科；

2001年-2004年：澳大利亚墨尔本大学皇家墨尔本医院；（博士）

2004年-2005年：美国加利福尼亚大学；

2006年-现在：天津市第一中心医院神经内科；

荣誉：

国家卫计委脑卒中防控中青年专家委员会常委；

中华医学会天津市神经病学分会副主任委员；

天津市脑卒中质控委员会副主任委员；

天津市医师协会神经内科分会副会长；

天津市神经科学学会常务理事；

天津市心身学会副主任委员；

9个SCI收录国际杂志特约审稿专家；

中华医学杂志海外版及国内版审稿专家；

国家食药监局医疗器械技术专家；

天津市食药监局医疗器械技术专家；

天津市劳动伤残鉴定专家；

天津市医疗纠纷人民调解委员会专家；

天津市预防接种异常反应调查诊断专家组成员；

天津市计划生育医学鉴定专家；

天津市科委科技获奖评审专家；

天津市行政许可评审专家；

天津市“131”人才工程第一层次人选；

天津市百名优秀留学回国人员；

发表文章：

1.     Liu J, Gao LN, Zang DW (通讯作者). "Elevated Levels of IFN-gamma in CSF and Serum of Patients with Amyotrophic Lateral Sclerosis." Plos One, 2015. 10(9): e0136937. PMID: 26332465.

2.     Guo J, Yang X, Gao L, Zang DW (通讯作者). Evaluating the levels of CSF and serum factors in ALS. Brain Behav. 2017 Feb 19;7(3):e00637. PMID: 28293476.

3.     Zheng Y, Gao L, Wang D, Zang DW (通讯作者). Elevated levels of ferritin in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Acta Neurol Scand. 2016 Nov 1. doi: 10.1111/ane.12708. PMID: 27804118.

4.     Zhang R, Zang DW (通讯作者). Mechanism of neuroprotective effects of fibroblast growth factor 2 in the mouse model of ALS. Zhonghua Yi Xue Za Zhi. 2016 Mar 22;96(11):886-90. PMID: 27045653.

5.     Yang X, Gao LN, Wu XY, Zhang Y, Zang DW (通讯作者). Increased levels of MIP-1alpha in CSF and serum of ALS.  Acta Neurol Scand. 2015, Oct 2. doi: 10.1111/ane.12513. PMID: 26427609.

6.     Gong ZY, Gao LN, Guo J, Lu Y, Zang DW (通讯作者). "bFGF in the CSF and serum of sALS patients." Acta Neurol Scand. 2015, Sep;132(3):171-8. PMID: 25631037.

7.     Li, YB, Zang DW (通讯作者). The Neuron Regrowth Is Associated with the Proliferation of Neural Precursor Cells after Leukemia Inhibitory Factor Administration following Spinal Cord Injury in Mice. Plos One, 2014. 9(12): p. e116031. PMID: 25542011.

8.     Song Y, Zang DW, Jin YY, Wang ZJ, Ni HY, Yin JZ, Ji DX. Background rhythm frequency and theta power of quantitative EEG analysis: predictive biomarkers for cognitive impairment post-cerebral infarcts. Clin EEG Neurosci. 2015 Apr;46(2):142-6.

9.     Gao LN, Zhou SD, Cai HW, Gong ZY, Zang DW (通讯作者). VEGF levels in CSF and serum in mild ALS patients. J Neurol Sci, 2014, Nov 15;346(1-2):216-20. PMID: 25204587.

10. Huang WH, Zang DW (通讯作者), Lu Y, Jiang P. Basic fibroblast growth factor increases the number of endogenous neural stem cells and inhibits the expression of amino methyl isoxazole propionic acid receptors in amyotrophic lateral sclerosis mice. Neural Regen Res, 2012. 7(10): p. 761.

11. Huang WH, Li YD, Lin YF, Ye X, Zang DW (通讯作者). Effects of leukemia inhibitory factor and basic fibroblast growth factor on free radicals and endogenous stem cell proliferation in a mouse model of cerebral infarction. Neural Regen Res, 2012. 7(19): p. 1469.

12. Lin YF, Li YD, Zang DW (通讯作者). Effects of leukemia inhibitory factor on endogenous neural stem cell proliferation and glycoprotein-130 expression in a mouse model of cerebral infarction. Neural Regen Res, 2011; 6(19):1452-1456.

13. Zang DW (通讯作者), Liu J, Gong ZY. LIF Promotes the expression of synaptophysin on motor neurons of FALS. Amyotrophic Lateral Sclerosis. 2009 Nov;10(1)85.

14. Ma CC, Liu J, Zang DW (通讯作者). LIF decreases AMPA receptors in the brainstem and sensorimotor cortex of SOD1G93AG1H mouse model of ALS. Amyotrophic Lateral Sclerosis. 2009 Nov; 10(1)79.

15. Liu J, Zang DW (通讯作者). Response of neural precursor cells in the brain of Parkinson's disease mouse model after LIF administration. Neurol Res. 2008 Dec 23. PMID: 19108756.

16. Liu J, Zang DW (通讯作者), Julie AD. Increased number and differentiation of neural precursor cells in the brainstem of superoxide dismutase 1(G93A) (G1H) transgenic mouse model of amyotrophic lateral sclerosis. Neurol Res. 2007 Mar;29(2):204-9. PMID: 17439705.

17. Zang DW, Lopes EC, Cheema SS. Loss of synaptophysin-positive boutons on lumbar motor neurons innervating the medial gastrocnemius muscle of the SOD1G93A G1H transgenic mouse model of ALS. J Neurosci Res. 2005 Mar 1;79(5):694-9. PMID: 15668955.

18. Zang DW, Yang Q, Wang HX, Egan G, Lopes EC, Cheema SS. Magnetic resonance imaging reveals neuronal degeneration in the brainstem of the superoxide dismutase 1 transgenic mouse model of amyotrophic lateral sclerosis. Eur J Neurosci. 2004 Oct;20(7):1745-51. PMID: 15379995.

19. Zang DW, Cheema SS. Leukemia inhibitory factor promotes recovery of locomotor function following spinal cord injury in the mouse. J Neurotrauma. 2003 Nov;20(11):1215-22. PMID: 14651808.

20. Zang DW, Cheema SS. Degeneration of corticospinal and bulbospinal systems in the superoxide dismutase 1(G93A G1H) transgenic mouse model of familial amyotrophic lateral sclerosis. Neurosci Lett. 2002 Oct 31;332(2):99-102. PMID: 12384220.

21. Azari MF, Karnezis T, Bernard CC, Profyris C, LeGrande MR, Zang DW, Cheema SS, Petratos S. Incomplete Freund's adjuvant enhances locomotor performance following spinal cord injury. Eur J Neurol. 2005 Dec;12(12):1004-8. PMID: 16324097.

22. Azari MF, Profyris C, Zang DW, Petratos S, Cheema SS. Induction of endogenous neural precursors in mouse models of spinal cord injury and disease. Eur J Neurol. 2005 Aug;12(8):638-48. PMID: 16053474.

23. Turner BJ, Atkin JD, Farg MA, Zang DW, Rembach A, Lopes EC, Patch JD, Hill AF, Cheema SS. Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis. J Neurosci. 2005 Jan 5;25(1):108-17. PMID: 15634772.

24. Profyris C, Cheema SS, Zang DW, Azari MF, Boyle K, Petratos S. Degenerative and regenerative mechanisms governing spinal cord injury. Neurobiol Dis. 2004 Apr;15(3):415-36. PMID: 15056450.

25. Azari MF, Lopes EC, Stubna C, Turner BJ, Zang DW, Nicola NA, Kurek JB, Cheema SS. Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A G1H) mouse model of familial amyotrophic lateral sclerosis. Brain Res, 2003 Aug 22;982(1):92-7. PMID: 12915243.

26. Song Y, Zang DW, Wang ZY, Guo J, Gong ZY. Research Article Grand Total EEG Analyses: A Promising Method Predict The Severity of Cognitive Impairment in Alzheimer's Disease. Journal of Neurological Sciences;2014, Vol. 31 Issue 1, p40-46. (Accession: 95382459).

27. Liu Y, Peng M, Zang DW, Zhang BS. Leukemia inhibitory factor promotes nestin-positive cells, and increases gp130 levels in the Parkinson disease mouse model of 6-hydroxydopamine. Neurosciences (Riyadh). 2013 Oct;18(4):363-70.

28. Liu J, Zang DW (通讯作者), Cheema SS. Synaptophysin expression in motor neurons of transgenic mice with amyotrophic lateral sclerosis. Neural Regen Res, 2006, 1(8):750-752.

29. Zang DW (通讯作者), Liu J, Cheema SS. Effect of neurotrophic factor and stem cell therapy on alregeneration after spinal cord injury. Journal of Clinical Rehabilitative Tissue Engineer Research, 2007. 11(14): p. 2787-2791.

影响因子：

累计IF一百余分，被引用次数：2103，其中自引次数58次。

资金支持：

承担国际合作、国际级、天津市科委及天津市卫生局科研课题15项。

其他：

获得天津市科技进步二等奖2次，国际先进及国内领先科技成果12项。国际PCT及国内发明专利16项。